Dimethyl Sulfoxide
Apexbio Technology LLC LY2228820 862507-23-1 10mM (in 1mL DMSO)
LY2228820 (CAS 862507-23-1) is a potent selective ATP-competitive small-molecule inhibitor targeting the and isoforms of p38 mitogen-activated protein kinase (MAPK) with reported IC50 values of 5 3 nM and 3 2 nM respectively By suppressing p38 MAPK signaling LY2228820 decreases phosphorylation of heat shock protein 27 (HSP27) induced by Bortezomib thereby elevating cytotoxic effects in multiple myeloma (MM) models Additionally it inhibits secretion of IL-6 by bone marrow mononuclear cells and stromal cells as well as secretion of MIP-1 by patient-derived MM cell subsets and osteoclast precursors In melanoma (B16-F10) and NSCLC (A549) xenograft murine models LY2228820 reduces phosphorylation of MK2 and slows tumor progression respectively highlighting its potential utility in oncology research
Apexbio Technology LLC Micafungin sodium 208538-73-2 10mM (in 1mL DMSO)
Micafungin sodium is an antifungal agent that acts by inhibiting the synthesis of 1 3- -D-glucan an essential polymer for fungal cell wall integrity particularly in Candida albicans In addition to antifungal activities micafungin has been studied for its capacity to suppress biofilm formation by Pseudomonas aeruginosa via downregulation of genes encoding structural biofilm elements such as algC and pelC and the 1 3- -D-glucan-encoding gene ndvB Micafungin has demonstrated synergy with other antifungal compounds in animal models in murine models of systemic Aspergillus fumigatus infection micafungin administration resulted in increased survival rates Micafungin is utilized in biomedical research to investigate antifungal mechanisms combination therapies and inhibition of pathogen biofilms Reported inhibitory activity (IC50) for fungal glucan synthase typically falls within the nanomolar range
Apexbio Technology LLC G007-LK 1380672-07-0 10mM (in 1mL DMSO)
G007-LK (CAS 1380672-07-0) is a small molecule inhibitor that selectively targets tankyrase 1 and 2 (TNKS1/2) enzymes within the poly(ADP-ribose) polymerase family that modulate protein complexes through ADP-ribosylation G007-LK inhibits TNKS1 and TNKS2 with IC50 values of 46 nM and 25 nM respectively reducing their auto-poly(ADP-ribosylation) activity Treatment with G007-LK decreases -catenin levels in APC-mutated colorectal cancer cells by promoting formation of -catenin degradation complexes In xenograft mouse models using COLO-320DM cells G007-LK administration suppresses tumor growth dose-dependently indicating its utility in oncology research focusing on the Wnt/ -catenin pathway
Apexbio Technology LLC Matrine(Synonyms: Sophocarpidine, Matridin, (-)-Matrine, α-Matrine, (−)-α-Matrine, L-Matrine, Kushenin), 10mM (in 1mL DMSO), CAS: 519-02-8.
Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation
Apexbio Technology LLC A-740003(Synonyms: A740003, A 740003, P2X7 Receptor Antagonist A-740003, A-740003 P2X7 Antagonist, 861393-28-4), 10mM (in 1mL DMSO), CAS: 861393-28-4.
A-740003 (CAS 861393-28-4) is a selective and competitive antagonist targeting the P2X7 receptor a member of the ATP-gated ionotropic P2X receptor family involved in immune cell signaling cytokine secretion apoptosis and cellular proliferation The antagonist displays IC50 values of 18 nM and 40 nM against mouse and human P2X7 receptors respectively In human THP-1 macrophage-like cells A-740003 inhibits pore formation assessed by Yo-Pro uptake assay (IC50 92 nM) and reduces interleukin-1 secretion (IC50 156 nM) This compound is employed in research investigating P2X7-mediated inflammatory pathways and neuropathic pain mechanisms
Apexbio Technology LLC PD 173074 219580-11-7 10mM (in 1mL DMSO)
PD 173074 (CAS 219580-11-7) is a selective inhibitor targeting fibroblast growth factor receptors (FGFR) exerting its effects by suppressing FGFR tyrosine kinase phosphorylation It has demonstrated dose-dependent inhibitory activity against small cell lung cancer (SCLC) cell lines including H-510 and H-69 by reducing their proliferation colony formation and FGF-2 induced chemotherapy resistance in vitro In murine xenograft models of SCLC PD 173074 reduced tumor progression and significantly prolonged animal survival achieving durable complete responses in some cases PD 173074 represents an important tool compound for investigating the oncogenic role of FGFR signaling in cancer research
Apexbio Technology LLC Birinapant (TL32711) 1260251-31-7 10mM (in 1mL DMSO)
Birinapant (TL32711) is a potent antagonist of XIAP and cIAP proteins binding specifically to their BIR domains with Kd values around 45 nM for XIAP and below 1 nM for cIAP1 By promoting rapid degradation of TRAF2-associated cIAP1 and cIAP2 Birinapant suppresses TNF-induced NF- B signaling and facilitates the assembly of RIPK1-dependent caspase-8 complexes thus initiating downstream apoptosis pathways It has been widely employed in biomedical research to investigate apoptosis mechanisms and tumor resistance In melanoma and breast cancer models Birinapant combined with cytokines such as TNF- led to tumor cell growth suppression and sensitized therapy-resistant cells to apoptosis
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 10mM (in 1mL DMSO)
SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy
Medchemexpress LLC Puromycin 10 Mm 1 Ml In Dmso | HY-B1743-10 MM 1 ML IN
Puromycin 10 Mm 1 Ml In Dmso
Apexbio Technology LLC Salirasib 162520-00-5 10mM (in 1mL DMSO)
Salirasib (CAS 162520-00-5) chemically known as S-trans trans-farnesylthiosalicylic acid (FTS) is a synthetic inhibitor targeting Ras proteins Structurally mimicking the carboxy-terminal farnesylated cysteine found in Ras Salirasib disrupts Ras localization at the cellular membrane thereby reducing activity of H-ras K-ras and N-ras isoforms Research indicates that Salirasib reduces Ras protein levels by approximately 50% at concentrations of 25 50 M in Panc-1 pancreatic cancer cells In xenograft models it exhibits tumor growth inhibition alone and synergistically with gemcitabine Clinical phase I studies support its continued investigation in solid-tumor therapy recommending a dose of 600 mg/day
Apexbio Technology LLC ML-323(Synonyms: ML323, ML 323, USP1 inhibitor ML323, ML-323 USP1-UAF1 inhibitor, USP1/UAF1 inhibitor ML323), 10mM (in 1mL DMSO), CAS: 1572414-83-5.
ML-323 (CAS 1572414-83-5) is a small molecule inhibitor selectively targeting the USP1-UAF1 deubiquitinase complex with a reported IC50 of 76 nM USP1-UAF1 participates in DNA damage response pathways by regulating ubiquitination status of proteins such as PCNA and FANCD2 In cellular assays ML-323 inhibits USP1 UAF1-mediated deubiquitination enhancing cisplatin-induced cytotoxicity in human NSCLC (H596) and osteosarcoma (U2OS) cells The molecule shows minimal cytotoxicity alone and exhibits high selectivity over other human DUBs and protease families providing a valuable research tool for DNA repair and cancer biology studies
Apexbio Technology LLC Bindarit 130641-38-2 10mM (in 1mL DMSO)
Bindarit (CAS 130641-38-2) also known as AF-2838 is a synthetic small-molecule inhibitor targeting the CC chemokines MCP-1 (CCL2) MCP-2 (CCL8) and MCP-3 (CCL7) By suppressing the transcription and production of MCP proteins Bindarit reduces monocyte chemoattraction and inflammation In vitro data indicate that Bindarit inhibits LPS-induced MCP-1 synthesis in monocytes with an IC50 around 172 M and selectively decreases MCP expression without impacting unrelated cytokines such as IL-6 or IL-8 Animal studies demonstrate its potential to reduce inflammatory cell infiltration vascular smooth muscle cell proliferation and neointimal hyperplasia in rodent injury models highlighting its value for inflammation and cardiovascular disease research
Apexbio Technology LLC Vorapaxar 618385-01-6 10mM (in 1mL DMSO)
Vorapaxar (CAS 618385-01-6) is a selective inhibitor of protease-activated receptor 1 (PAR1) a G-protein coupled receptor activated by thrombin-mediated cleavage on platelet surfaces leading to platelet activation Derived from the natural product himbacine vorapaxar directly binds PAR1 inhibiting platelet aggregation induced by thrombin receptor-activating peptides (IC 25 nM) and thrombin itself (IC 47 nM) In phase III clinical trials in patients daily oral administration reduced the incidence of cardiovascular death or ischemic events highlighting its relevance as an antithrombotic research agent
Apexbio Technology LLC Nitrendipine 39562-70-4 10mM (in 1mL DMSO)
Nitrendipine (CAS number 39562-70-4) is a dihydropyridine derivative acting as a calcium channel antagonist that selectively inhibits L-type calcium channels By blocking calcium ion influx into vascular smooth muscle cells nitrendipine induces vasodilation and reduces peripheral vascular resistance thereby lowering arterial blood pressure Due to its vascular-selective calcium antagonism it serves as a pharmacological tool in cardiovascular research particularly for studying mechanisms of hypertension and calcium-dependent signaling pathways
Apexbio Technology LLC PD318088 391210-00-7 10mM (in 1mL DMSO)
PD318088 (CAS 391210-00-7) is an allosteric non-ATP competitive inhibitor of MEK1/2 kinase activity Structurally related to PD184352 it interacts adjacent to the ATP-binding site of MEK1 in proximity to residues Ile216 Phe209 Arg189 and Asp190 stabilizing a ternary complex involving MEK1/2 and MgATP This binding moderately increases the dissociation constant (Kd) for the MEK dimerization state from 75 nM to 140 nM PD318088 is mainly utilized as a molecular tool in protein kinase signaling research particularly in pathways involving MEK1/2